Pyruvate Kinase Deficiency (PKDef)
Erythrocyte Pyruvate Kinase Deficiency (PK Deficiency) is an inherited hemolytic anemia caused by insufficient activity of this regulatory enzyme which results in instability and loss of red blood cells. The anemia is intermittent, the age of onset is variable and clinical signs are also variable.
Susceptibility to Pug Dog Encephalitis (PDE)
Susceptibility to Pug Dog Encephalitis (PDE) Approximately 1.2% of Pug dogs die of necrotizing meningoencephalitis (NME), also known as Pug dog encephalitis (PDE). NME is an inflammatory disease of the central nervous system that is usually progressive and fatal. Symptoms of NME include seizures, depression, ataxia, abnormal gait and blindness.
MD SOD1- A
Degenerative Myelopathy (DM) is a progressive neurodegenerative disease that occurs in many breeds of dogs. he disease is an adult-onset condition that has ALS like symptoms: progressive limb weakness and muscle loss, tremors, difficulty rising and stumbling. Affected animals develop spinal and hind end problems later in life. It is inherent as a recessive disease based on these mutations. Causing paralysis.